Dr Jyothi Rengarajan - Lung Immunometabolic Networks Regulating Infection to M. tuberculosis and HIV

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Jyothi Rengarajan --------------------- Emory Vaccine Center Lung Immunometabolic Networks Regulating Infection to M. tuberculosis and HIV This seminar explores how mitochondrial metabolism and macrophage-T cell communication shape protective lung immunity to tuberculosis, and why people living with HIV remain more susceptible to TB despite antiretroviral therapy. Jyothi Rengarajan is Professor of Medicine at Emory University and Co-Director of the Emory/Georgia Tuberculosis Research Advancement Center. She earned her BSc at St. Xavier's College, Bombay University, her MS at Carnegie Mellon University, and her PhD at Harvard University, followed by postdoctoral research at the Harvard School of Public Health. Her laboratory studies how Mycobacterium tuberculosis evades host immunity and how HIV co-infection alters immune protection. Combining experimental models with clinical collaborations, her work informs the development of TB vaccines, host-directed therapies, and diagnostic biomarkers. Selected publications • Enriquez AB et al. Mycobacterium tuberculosis impedes CD40-dependent notch signaling to restrict Th17 polarization during infection. Science. 2022;25(5):104305. doi:10.1016/j.isci.2022.104305. • Sharan R et al. Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus confection model. J Clin Invest. 2022;132(3). doi:10.1172/JC|153090. • Ganatra SR et al. Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV confection model. J Clin Invest. 2020;130(10):5171-5179. doi:10.1172/JC|136502. This Prestige seminar is supported by the B2S Federation.